abstract：:Reversible posterior leukoencephalopathy syndrome (RPLS) is an uncommon but distinctive clinicoradiological entity comprising of headache, seizures, visual disturbance, and altered mental function, in association with posterior cerebral white matter edema. With appropriate management, RPLS is reversible in the majorit...

journal_title：American journal of hematology

authors： Tam CS,Galanos J,Seymour JF,Pitman AG,Stark RJ,Prince HM

更新日期：2004-09-01 00:00:00

abstract：:Hemophagocytic syndrome (HPS) is an unusual acute syndrome presenting with fever, hepatosplenomegaly, and cytopenias. The hallmark of HPS is the accumulation of activated macrophages that engulf hematopoietic cells in the reticuloendothelial system. Most cases of HPS in adults are secondary to infection or malignancy,...

journal_title：American journal of hematology

authors： Goldschmidt N,Gural A,Kornberg A,Spectre G,Shopen A,Paltiel O

更新日期：2004-08-01 00:00:00

abstract：:While systemic plasma endothelin-1 (ET-1) levels are increased during acute crisis in sickle cell disease, the relative levels of potent vasoactive factors that contribute to the regulation of vascular function, such as ET-1, NO, and cell-free hemoglobin, during the course of periodic vaso-occlusive episodes remain un...

journal_title：American journal of hematology

authors： Ergul S,Brunson CY,Hutchinson J,Tawfik A,Kutlar A,Webb RC,Ergul A

更新日期：2004-07-01 00:00:00

abstract：:Thromboembolic complications following splenectomy for hematologic diseases occur in up to 10% of patients and may range from portal vein thrombosis (PVT) to pulmonary embolism (PE) and deep vein thrombosis (DVT). Up to now there exist no recommendations for the duration and intensity of prophylactic anticoagulation, ...

journal_title：American journal of hematology

authors： Mohren M,Markmann I,Dworschak U,Franke A,Maas C,Mewes S,Weiss G,Jentsch-Ullrich K

更新日期：2004-06-01 00:00:00

abstract：:This paper describes, for the first time, the utilization of nebulized morphine in the management of severe chest pain in two young adult African-American patients who suffered from generalized acute sickle cell painful episodes. While hospitalized, both patients developed new sharp chest wall pain, and were treated w...

journal_title：American journal of hematology

authors： Ballas SK,Viscusi ER,Epstein KR

更新日期：2004-06-01 00:00:00

abstract：:We analyzed the genetic defects of 21 unrelated patients with venous thrombosis in whom hereditary protein C deficiency was diagnosed. Eleven mutations were detected in 18 families, while no mutation was detectable in the other three families. Among these mutations, a common genetic mutation of protein C (PROC) gene r...

journal_title：American journal of hematology

authors： Tsay W,Shen MC

更新日期：2004-05-01 00:00:00

abstract：:We report a patient with incapacitating POEMS syndrome characterized by serum monoclonal protein, polyneuropathy, organomegaly, endocrinopathy, mesangiocapillary glomerulonephritis, massive ascites formation, and pulmonary hypertension. A dramatic improvement in the clinical condition occurred after administration of ...

journal_title：American journal of hematology

authors： Sinisalo M,Hietaharju A,Sauranen J,Wirta O

更新日期：2004-05-01 00:00:00

abstract：:A 28-year-old asymptomatic male of Iranian Jewish (Meshadi) heritage was found on routine exam to have an erythrocytosis (RBC = 6.22 x 10(12)/l, Hgb = 19.2 g/dl, Hct = 58.9%). Splenomegaly was absent on physical exam. There was no family history of erythrocytosis. His oxygen dissociation curve was left-shifted with a ...

journal_title：American journal of hematology

authors： Hoyer JD,Allen SL,Beutler E,Kubik K,West C,Fairbanks VF

更新日期：2004-04-01 00:00:00

abstract：:In patients with light-chain myeloma or primary AL-amyloidosis, 24-hr light-chain excretion in the urine is considered an essential marker of the tumor mass. However, 24-hr urine collection and analysis may be cumbersome and prone to inaccuracy. Recently, a sensitive immunonephelometric assay for immunoglobulin free l...

journal_title：American journal of hematology

authors： Alyanakian MA,Abbas A,Delarue R,Arnulf B,Aucouturier P

更新日期：2004-04-01 00:00:00

abstract：:Peptide-pulsed dendritic cells can stimulate T cells showing specific cytotoxicity in chronic myelogenous leukemia. We tried to induce a specific cytotoxic T-cell response stimulated by RNA-pulsed dendritic cells in acute myelogenous leukemia. The total RNA of WEHI-3BD+, a myelomonocytic leukemia cell line derived fro...

journal_title：American journal of hematology

authors： Jung CW,Kwon JH,Seol JG,Park WH,Hyun JM,Kim ES,Kim ST,Lee SJ,Kim BK,Lee YY

更新日期：2004-03-01 00:00:00

abstract：:Red blood cells from patients with sickle cell disease (SS RBC) adhere to laminin and over-express the high-affinity laminin receptor basal cell adhesion molecule/Lutheran protein (B-CAM/LU). This receptor has recently been shown to undergo activation in vitro through a protein kinase A-dependent mechanism. Low-densit...

journal_title：American journal of hematology

authors： Zen Q,Batchvarova M,Twyman CA,Eyler CE,Qiu H,De Castro LM,Telen MJ

更新日期：2004-02-01 00:00:00

abstract：:The authors report a 10-year-old boy with hepatosplenic gammadelta T-cell lymphoma, a rare form of lymphoma that is highly aggressive, exceedingly rare in children, and primarily seen in young men. Conventional multi-agent chemotherapy appears to be inadequate for cure. This is the first report with this type of lymph...

journal_title：American journal of hematology

authors： Gassas A,Kirby M,Weitzman S,Ngan B,Abla O,Doyle JJ

更新日期：2004-02-01 00:00:00

abstract：:We investigated the rare case of a patient with IgGlambda multiple myeloma for whom both prothrombin time and APTT were significantly prolonged. The IgG inhibited coagulation reactions upstream from prothrombin when coagulation was initiated by mRVVT, but not by FXa, as indicated by a chromogenic substrate for FXa. Th...

journal_title：American journal of hematology

authors： Takamiya O,Machida S,Okuda M,Nojima J,Koreeda C,Kubara K

更新日期：2004-01-01 00:00:00

abstract：:Intravenous anti-D immune globulin (anti-D IGIV) is indicated for the treatment of immune thrombocytopenic purpura (ITP) in nonsplenectomized patients who are Rh(D)-positive. Recent reports have described episodes of intravascular hemolysis (IVH) and acute renal failure (ARF) after anti-D IGIV. We report the first adu...

journal_title：American journal of hematology

authors： Chun NS,Savani B,Seder RH,Taplin ME

更新日期：2003-12-01 00:00:00

abstract：:Neutrophil elastase (NE) is a serine protease stored in the primary granules of neutrophils that proteolytically cleaves multiple cytokines and cell surface proteins on release from activated neutrophils. Recent reports of mutations in the gene encoding this enzyme in some patients with neutropenic syndromes prompted ...

journal_title：American journal of hematology

authors： Hunter MG,Druhan LJ,Massullo PR,Avalos BR

更新日期：2003-11-01 00:00:00

abstract：:We report a case of a 61-year-old man with head and neck cancer who presented with pancytopenia two months after the completion of his chemotherapy and was diagnosed with myelodysplasia on the basis of two bone marrow examinations, before the correct diagnosis of visceral leishmaniasis was established with splenectomy...

journal_title：American journal of hematology

authors： Kopterides P,Halikias S,Tsavaris N

更新日期：2003-11-01 00:00:00

abstract：:We describe a 23-year-old retired military officer who was immunocompetent but diagnosed with hemophagocytic syndrome (HPS) by Plasmodium vivax infection. Initially, the patient was suspected to have toxic hepatitis related to heavy drinking. But abnormal hematologic findings required a further bone marrow examination...

journal_title：American journal of hematology

authors： Park TS,Oh SH,Choi JC,Kim HH,Chang CL,Son HC,Lee EY

更新日期：2003-10-01 00:00:00

abstract：:Bacterial and protozoal infections can cause thrombocytopenia and may mimic idiopathic thrombocytopenic purpura (ITP). Brucella species and Toxoplasma are among the infectious agents with protean clinical manifestations which may induce immune thrombocytopenia. In rare cases, thrombocytopenia can be severe and may res...

journal_title：American journal of hematology

authors： Gürkan E,Başlamişli F,Güvenç B,Bozkurt B,Unsal C

更新日期：2003-09-01 00:00:00

abstract：:Febrile neutropenia (FN) is a frequent complication of cancer chemotherapy, which causes death in 4-21% of patients and worsens the quality of life of patients. As a simple and accurate way of identifying patients who are at risk of FN, a lymphocyte count on post-chemotherapy day 5 was suggested. To confirm the feasib...

journal_title：American journal of hematology

authors： Choi CW,Sung HJ,Park KH,Yoon SY,Kim SJ,Oh SC,Seo JH,Kim BS,Shin SW,Kim YH,Kim JS

更新日期：2003-08-01 00:00:00

abstract：:This study investigated the clinical characteristics and prognostic relevance of CD34 expression in 47 patients with acute promyelocytic leukemia (APL), showing t(15;17) or PML/RARalpha. Ten (21.3%) of the APL patients were CD34(+). CD34 expression was associated with hypogranular morphology (P = 0.002) and hyperleuko...

journal_title：American journal of hematology

authors： Lee JJ,Cho D,Chung IJ,Cho SH,Park KS,Park MR,Ryang DW,Kim HJ

更新日期：2003-07-01 00:00:00

abstract：:In addition to transferrin, ferritin can also function as a source of iron for heme synthesis (Gelvin D, et al. Blood 1996;88:3200-3207; Meyron-Holtz EG, et al. Blood 1999;94:3205-3211). In the present study we investigate the effect of external ferritin on the proliferation and hemoglobinization of human erythroid pr...

journal_title：American journal of hematology

authors： Leimberg JM,Konijn AM,Fibach E

更新日期：2003-07-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) therapy is associated with rare reports of thromboembolic events and severe hyponatremia. We hypothesized that IVIG therapy may result in hyperproteinemia, increased serum viscosity, and pseudohyponatremia. We conducted a prospective observational study to evaluate the incidence of hy...

journal_title：American journal of hematology

authors： Steinberger BA,Ford SM,Coleman TA

更新日期：2003-06-01 00:00:00

abstract：:Platelet antibodies are detectable in only about 50% of patients with chronic autoimmune thrombocytopenia (AITP). We determined platelet antibodies against GPIa/IIa, GPIb/IX, GPIIb/IIIa, and GPV and reticulated platelets in three female patients with AITP, before and after immunoadsorption treatment. None of the three...

journal_title：American journal of hematology

authors： Leitner GC,Stiegler G,Horvath M,Hoecker P,Sagaster P,Panzer S

更新日期：2003-05-01 00:00:00

abstract：:We report the case of a 59-year-old woman with Durie-Salmon stage IIIB IgGkappa multiple myeloma (MM), who presented 83 days after autologous hematopoietic stem cell transplant (HSCT) with multiple subcutaneous plasmacytomas. These lesions were confined exclusively to sites where the patient had sustained local trauma...

journal_title：American journal of hematology

authors： Rosenblum MD,Bredeson CN,Chang CC,Rizzo JD

更新日期：2003-04-01 00:00:00

abstract：:Anemia is a major cause of morbidity and mortality among patients with sickle cell anemia. In this study, 108 episodes of severe anemia were prospectively evaluated in 108 patients with hemoglobin SS disease attending the pediatric sickle cell clinic of the University of Nigeria Teaching Hospital, Enugu, Nigeria. Youn...

journal_title：American journal of hematology

authors： Juwah AI,Nlemadim A,Kaine W

更新日期：2003-03-01 00:00:00

abstract：:Severe chronic neutropenia (SCN) is defined as an absolute neutrophil (ANC) of less than 0.5 x 10(9)/L, lasting for months or years. Congenital, cyclic, and idiopathic neutropenia are principal categories of SCN. Since 1994, the Severe Chronic Neutropenia International Registry (SCNIR) has collected data to monitor th...

journal_title：American journal of hematology

authors： Dale DC,Cottle TE,Fier CJ,Bolyard AA,Bonilla MA,Boxer LA,Cham B,Freedman MH,Kannourakis G,Kinsey SE,Davis R,Scarlata D,Schwinzer B,Zeidler C,Welte K

更新日期：2003-02-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (HSCT) represents the only curative option for primary hemophagocytic lymphohistiocytosis (HLH), a rare disease of infants and young children, characterized by recurrent fever, hepatosplenomegaly, and cytopenia. We report a case of successful engraftment and stable fu...

journal_title：American journal of hematology

authors： Cesaro S,Gazzola MV,Marson P,Calore E,Caenazzo L,Destro R,De Silvestro G,Varotto S,Pillon M,Zanesco L,Messina C

更新日期：2003-02-01 00:00:00

abstract：:We measured the plasma level of fibrinogen in 560 patients with disseminated intravascular coagulation (DIC) and evaluated its relationship with outcome and with other hemostatic markers. Forty-seven percent of patients had >200 mg/dL of plasma fibrinogen and 24% had <100 mg/dl of plasma fibrinogen, suggesting that pl...

journal_title：American journal of hematology

authors： Wada H,Mori Y,Okabayashi K,Gabazza EC,Kushiya F,Watanabe M,Nishikawa M,Shiku H,Nobori T

更新日期：2003-01-01 00:00:00

abstract：:A rare beta-thalassemia mutation at the splicing junction [namely, G-->C in intervening sequence (IVS) I-1] was found in a Japanese family. The proband and his mother were heterozygous for the mutation. Analysis of mRNA extracted from the reticulocyte-rich fraction obtained from the proband's mother revealed that the ...

journal_title：American journal of hematology

authors： Fujihara N,Tozuka M,Ueno I,Yamauchi K,Nakagoshi R,Ishikawa S,Hirota M,Okumura N,Ishii E,Katsuyama T

更新日期：2003-01-01 00:00:00

abstract：:Factor V G1691A (FV-Leiden) and prothrombin G20210A mutations are major inherited risk factors for venous thrombosis. Recently, it was suggested that both mutations, through stimulation of venous and placental thrombosis events, were strongly associated with recurrent idiopathic miscarriages, although other studies di...

journal_title：American journal of hematology

authors： Finan RR,Tamim H,Ameen G,Sharida HE,Rashid M,Almawi WY

更新日期：2002-12-01 00:00:00

abstract：:Thrombocytopenia is a poor prognostic indicator in the myelodysplastic syndromes (MDS). Treatment options for patients with symptomatic thrombocytopenia are limited. Danazol, an attenuated androgen, may have some efficacy in increasing the platelet count of patients with MDS. We retrospectively reviewed 33 patients wi...

journal_title：American journal of hematology

authors： Chan G,DiVenuti G,Miller K

更新日期：2002-11-01 00:00:00

abstract：:The purpose of this study was to determine if therapeutic levels of Rituximab could be achieved in a patient with renal failure being dialyzed and if Rituximab is removed by hemodialysis. A 54-year-old man with low-grade lymphoma and renal failure on hemodialysis received 8 weekly treatments of Rituximab at 375 mg/M(2...

journal_title：American journal of hematology

authors： Jillella AP,Dainer PM,Kallab AM,Ustun C

更新日期：2002-11-01 00:00:00

abstract：:The hereditary persistence of fetal hemoglobin (HPFH)-6 is sporadically found in Thailand whereas the deletion-inversion type (G)gamma((A)gamma delta beta)(0)-thalassemia is described among Indians. We report a hitherto un-described case in which these two defects co-segregate. He was a 3-year-old Thai boy who had a f...

journal_title：American journal of hematology

authors： Fucharoen S,Pengjam Y,Surapot S,Fucharoen G,Sanchaisuriya K

更新日期：2002-10-01 00:00:00

abstract：:Ticlopidine-induced aplastic anemia (TIAA) is considered very uncommon. We present two new cases, and we review 55 additional cases from the literature. The first case concerns a 70-year-old man who developed severe aplastic anemia 7 weeks after treatment with 500 mg of ticlopidine daily. The patient sustained a sever...

journal_title：American journal of hematology

authors： Symeonidis A,Kouraklis-Symeonidis A,Seimeni U,Galani A,Giannakoulas N,Fragopanagou E,Tiniakou M,Matsouka P,Zoumbos N

更新日期：2002-09-01 00:00:00

abstract：:Arsenic trioxide (As(2)O(3)) has been found effective in the treatment in the treatment of acute promyelocytic leukemia (APML). Most studies with As(2)O(3) involve patients with APML who have relapsed following standard therapy. Between January 1998 and July 2000, 14 patients were recruited for an ongoing trial of As(...

journal_title：American journal of hematology

authors： Mathews V,Balasubramanian P,Shaji RV,George B,Chandy M,Srivastava A

更新日期：2002-08-01 00:00:00

abstract：:We studied levels of plasma endothelin-1 (ET-1) in 25 beta-thalassemia/Hb E patients before and after blood transfusion. Baseline ET-1 levels in these patients were significantly higher than in normal controls (10.17 +/- 2.1 pg/mL vs. 8.9 +/- 2.0 pg/mL, P < 0.05). After blood transfusion, levels of plasma ET-1 tend to...

journal_title：American journal of hematology

authors： Viprakasit V,Kankirawatana S,Akarasereenont P,Durongpisitkul K,Chotewuttakorn S,Tanphaichitr VS

更新日期：2002-07-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is rarely complicated by chylothorax: we present a 93-year-old woman with CLL who developed recurrent pleural effusions that were ultimately found to be chylous in nature. Despite eight repeated thoracenteses, she continued to experience re-accumulation of fluid, and therefore, video...

journal_title：American journal of hematology

authors： Doerr CH,Staats BA,Markovic SN

更新日期：2002-07-01 00:00:00

abstract：:Four men were diagnosed with human immunodeficiency virus infection (AIDS) and autoimmune hemolytic anemia (HIV-AIHA) during the years 1997-2000 at Cook County Hospital, Chicago. All patients presented with the acute onset of severe hemolytic anemia, fever, and splenomegaly. The direct and indirect antiglobulin tests ...

journal_title：American journal of hematology

authors： Koduri PR,Singa P,Nikolinakos P

更新日期：2002-06-01 00:00:00

abstract：:We studied 15 patients with essential thrombocythemia (ET) before treatment and after normalization of platelet count by anagrelide. Significantly increased plasma levels of PDGF, TGFbeta, and bFGF were found. Patients with mild reticulin fibrosis in bone marrow had higher PDGF levels. During treatment, plasma TGFbeta...

journal_title：American journal of hematology

authors： Lev PR,Marta RF,Vassallu P,Molinas FC

更新日期：2002-06-01 00:00:00

abstract：:Pulmonary alveolar proteinosis (PAP) is a heterogeneous disease that occasionally develops with hematological malignancy. However, PAP in association with hematopoietic stem cell transplantation is quite rare. Here we present the first report of a patient who developed PAP after cord blood transplantation (CBT). A 45-...

journal_title：American journal of hematology

authors： Tomonari A,Shirafuji N,Iseki T,Ooi J,Nagayama H,Masunaga A,Tojo A,Tani K,Asano S

更新日期：2002-06-01 00:00:00